Antivenin-related Serum Sickness

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Antivenin-related serum sickness.

Serum sickness is a type III hypersensitivity reaction that occurs due to the deposition of excessive circulating immune complexes in patients treated with foreign proteins or haptens. Serum sickness induced by antivenin for snakebites has been frequently reported in the USA, but not in Taiwan. This difference may be due to the efficacy and dosage of antivenins administered to treat snakebites ...

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Serum Sickness in Rabbits I. Manifestations of Serum Sickness

The occurrence in man of reactions subsequent to a first injection of certain foreign proteins has long been recognized and, following the general use of antisera of various types, these reactions were thoroughly studied by von Pirquet and Schick (1) who gave the name serum sickness or serum disease to this phenomenon. I t was possible to study it quite extensively as it occurs in man. However,...

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Serum sickness and uveitis.

Serum sickness is immune response to a foreign antigen, usually a heterologous protein. Incidence rate is less than 0.5%. Antigens and responding antibodies form circulating immunocomplex that is characteristic for serum sickness. The condition occurs 7-15 days after exposure to the antigen, usually with clinical picture of glomerulonephritis. The immunocomplex circulates to other tissues where...

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Serum sickness-like reactions.

A serum sickness-like reaction (SSLR) to drug administration usually consists of cutaneous rash, arthralgia/arthritis, and, often, fever. This entity rarely has been discussed in the dermatologic literature. We describe the case of a 3-year-old girl with urticaria, fever, and arthralgia that appeared 8 days after starting cefaclor therapy for otitis media.

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Serum Sickness in Rabbits

1. The injection of a single large dose of normal horse serum into rabbits results in the appearance 3 to 8 days later of erythematous and edematous reactions on the ears in 68.9 per cent of the animals. 2. The injections may be given by any of several routes and reactions appear when the site of injection is definitely distant from the ears. 3. Injections of various antisera into rabbits cause...

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ژورنال

عنوان ژورنال: Journal of the Chinese Medical Association

سال: 2010

ISSN: 1726-4901

DOI: 10.1016/s1726-4901(10)70117-9